General Information:

Id: 7,848 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
article
Reference: Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599 [PMID: 17888544]

Interaction Information:

Comment In the MFG grey matter there was a significant increase in the lysine adduct of 4-HNE (4.9-fold) and, no significant difference in MFG white matter content of ApoE4 compared with ApoE3 AD brain.
Formal Description
Interaction-ID: 78338

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

4-Hydroxynonenal

in the MFG grey matter of ApoE4 compared with ApoE3 AD brain; (4.9-fold increase)