fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599
In the MFG grey matter there was a significant increase in the lysine adduct of 4-HNE (4.9-fold) and, no significant difference in MFG white matter content of ApoE4 compared with ApoE3 AD brain.
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