General Information:

Id: 7,848 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
article
Reference: Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599 [PMID: 17888544]

Interaction Information:

Comment The epsilon 4 allele of ApoE is associated with an earlier onset and faster progression of Alzheimer's disease in patients with the familial form of this neurodegenerative condition. ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.
Formal Description
Interaction-ID: 78037

gene/protein mutant

APOE (isoform E4)

increases_activity of

Comment The epsilon 4 allele of ApoE is associated with an earlier onset and faster progression of Alzheimer's disease in patients with the familial form of this neurodegenerative condition. ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.
Formal Description
Interaction-ID: 78301

gene/protein mutant

APOE (isoform E4)

decreases_activity of

in AD but not normal brain
Comment The epsilon 4 allele of ApoE is associated with an earlier onset and faster progression of Alzheimer's disease in patients with the familial form of this neurodegenerative condition. ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.
Formal Description
Interaction-ID: 78302

gene/protein mutant

APOE (isoform E4)

decreases_activity of

in AD but not normal brain
Comment In the MFG grey matter of AD patients with an ApoE4 genotype, there were increased levels of cholesterol, and the cholesterol esters C16:0, and C18:1 (range 2.6- to 3.4-fold).
Formal Description
Interaction-ID: 78329

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Cholesterol

in the MFG (middle frontal gyrus) grey matter of AD patients (in the cell bodies but not in the fiber tracks); compared with AD patients expressing ApoE3
Drugbank entries Show/Hide entries for
Comment In the MFG grey matter, there were significant decreases of sphingomyelin C22:0 (12.5-fold), and C24:0 (6.2-fold), and significant increases of ceramide C18:0 (2.0-fold) and C24:1 (1.8-fold) in ApoE4 compared with ApoE3 AD brain.
Formal Description
Interaction-ID: 78335

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

drug/chemical compound

SM C22:0

in the MFG grey matter in ApoE4 compared with ApoE3 AD brain; (12.5-fold decrease)
Comment In the MFG white matter, while there were no significant differences in sphingomeylin, there were significant differences in ceramide C22:0 (2.6-fold increase), C24:0 (1.2-fold decrease), and sulfatide (1.7-fold increase), in ApoE4 vs. ApoE3 brain.
Formal Description
Interaction-ID: 78337

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Ceramide C22:0

in the MFG white matter in ApoE4 vs. ApoE3 brain; (2.6-fold increase)
Comment In the MFG grey matter there was a significant increase in the lysine adduct of 4-HNE (4.9-fold) and, no significant difference in MFG white matter content of ApoE4 compared with ApoE3 AD brain.
Formal Description
Interaction-ID: 78338

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

4-Hydroxynonenal

in the MFG grey matter of ApoE4 compared with ApoE3 AD brain; (4.9-fold increase)
Comment Ceramides C18:0, C24:1 and sulfatide were increased in the MFG (middle frontal gyrus) grey matter of ApoE4 AD patients (1.8- to 2.0-fold).
Formal Description
Interaction-ID: 78339

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Ceramide C18:0

in the MFG grey matter of ApoE4 AD patients
Comment In the MTG (middle temporal gyrus) grey matter, only the cholesterol ester C18:1 was elevated (2.4-fold) in AD patients expressing ApoE4 compared with AD patients expressing ApoE3.
Formal Description
Interaction-ID: 78369

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Cholesterol ester C18:1

in the MTG (middle temporal gyrus) grey matter in AD patients expressing ApoE4, (in the cell bodies but not in the fiber tracks); (2.4-fold increase), compared with AD patients expressing ApoE3
Comment In the MFG grey matter of AD patients with an ApoE4 genotype, there were increased levels of cholesterol, and the cholesterol esters C16:0, and C18:1 (range 2.6- to 3.4-fold).
Formal Description
Interaction-ID: 78370

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Cholesterol ester C16:0

in the MFG (middle frontal gyrus) grey matter of AD patients (in the cell bodies but not in the fiber tracks); compared with AD patients expressing ApoE3
Comment In the MFG grey matter of AD patients with an ApoE4 genotype, there were increased levels of cholesterol, and the cholesterol esters C16:0, and C18:1 (range 2.6- to 3.4-fold).
Formal Description
Interaction-ID: 78371

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Cholesterol ester C18:1

in the MFG (middle frontal gyrus) grey matter of AD patients (in the cell bodies but not in the fiber tracks); compared with AD patients expressing ApoE3
Comment In the MFG grey matter, there were significant decreases of sphingomyelin C22:0 (12.5-fold), and C24:0 (6.2-fold), and significant increases of ceramide C18:0 (2.0-fold) and C24:1 (1.8-fold) in ApoE4 compared with ApoE3 AD brain.
Formal Description
Interaction-ID: 78372

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

drug/chemical compound

SM C24:0

in the MFG grey matter in ApoE4 compared with ApoE3 AD brain; (6.2-fold decrease)
Comment In the MFG white matter, while there were no significant differences in sphingomeylin, there were significant differences in ceramide C22:0 (2.6-fold increase), C24:0 (1.2-fold decrease), and sulfatide (1.7-fold increase), in ApoE4 vs. ApoE3 brain.
Formal Description
Interaction-ID: 78373

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

drug/chemical compound

Ceramide C24:0

in the MFG white matter in ApoE4 vs. ApoE3 brain; (1.2-fold decrease)
Comment In the MFG white matter, while there were no significant differences in sphingomeylin, there were significant differences in ceramide C22:0 (2.6-fold increase), C24:0 (1.2-fold decrease), and sulfatide (1.7-fold increase), in ApoE4 vs. ApoE3 brain.
Formal Description
Interaction-ID: 78374

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Sulfatide

in the MFG white matter in ApoE4 vs. ApoE3 brain; (1.7-fold increase)
Comment Ceramides C18:0, C24:1 and sulfatide were increased in the MFG (middle frontal gyrus) grey matter of ApoE4 AD patients (1.8- to 2.0-fold).
Formal Description
Interaction-ID: 78377

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Ceramide C24:1

in the MFG grey matter of ApoE4 AD patients
Comment Ceramides C18:0, C24:1 and sulfatide were increased in the MFG (middle frontal gyrus) grey matter of ApoE4 AD patients (1.8- to 2.0-fold).
Formal Description
Interaction-ID: 78378

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Sulfatide

in the MFG grey matter of ApoE4 AD patients