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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
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Schizophrenia

	Field	Term

General Information:

Id:	7,848 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Homo sapiens
Tissue/Cell line:	fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
Publication type:	article
Reference:	Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599 [PMID: 17888544]

Interaction Information:

Comment	The epsilon 4 allele of ApoE is associated with an earlier onset and faster progression of Alzheimer's disease in patients with the familial form of this neurodegenerative condition. ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.
Formal Description Interaction-ID: 78037	gene/protein mutant APOE (isoform E4) increases_activity of disease Alzheimer disease

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