General Information:

Id: 7,815 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
cognitively normal individuals (CN), aged 36–69 years, with a parental history of Alzheimer's disease;
article
Reference: Mielke MM et al.(2014) Cerebrospinal fluid sphingolipids, beta-amyloid, and tau in adults at risk for Alzheimers disease Neurobiol. Aging 35: 2486-2494 [PMID: 24952994]

Interaction Information:

Comment 91 individuals are included in this study. On average, participants were 53.4 (SD = 7.9) years of age, had 16 years of education, were overweight (mean BMI 27.8, SD = 5.5) and had normal levels of cholesterol, triglycerides, and blood glucose. There were 63 women (69.2%); 33 participants (36.3%) had at least one APOE E4 allele. All individuals were considered cognitively normal (CN) and had levels of Abeta and tau that are thought to be in the `normal' range. There was a significant, positive correlation between Abeta1-42 using the xMAP assay and AbetaX-42 using the MSD assay. Levels of CSF very long chain ceramides with chain lengths of C20–C26 were higher in APOE4 carriers compared to non-carriers.
Formal Description
Interaction-ID: 77782

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Ceramide C20-C26

in CSF in CN with a parental history of AD