General Information:

Id: 777 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0001103 skeletal muscle
Reference: Muller FL et al.(2007) Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 [PMID: 17584954]

Interaction Information:

Comment ROS production is increased in muscle mitochondria in mouse models of ALS and is correlated with the extent of muscle atrophy. State 1 ROS release during the disease course in G93A mice was increased almost 10-fold above levels in the mitochondria from wild-type mice, much higher than in the Sod1(-/-) mice or in old wild- type mice, which had relatively less muscle atrophy.
Formal Description
Interaction-ID: 4367

gene/protein mutant


increases_quantity of

drug/chemical compound

Reactive oxygen species

in skeletal muscle mitochondria