General Information:

Id: 772 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0001103 skeletal muscle
Reference: Muller FL et al.(2007) Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 [PMID: 17584954]

Interaction Information:

Comment ROS production is increased in muscle mitochondria during aging and is correlated with muscle atrophy. Gastrocnemius muscle mass was reduced nearly 13% at 28 mo in male wild-type mice and nearly 40% at 32 mo compared with 10-mo-old adult control mice.
Formal Description
Interaction-ID: 4357

drug/chemical compound

Reactive oxygen species

increases_activity of


muscle atrophy