General Information:

Id: 762
Diseases: Neurological
Parkinson disease
Rattus norvegicus
ventral mesencephalon precursor cell
article
Reference: Castelo-Branco G et al.(2004) GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons. J. Cell. Sci. 117: 5731-5737 [PMID: 15522889]

Interaction Information:

Comment GSK-3beta inhibition increases the number of DA neurons in ventral mesencephalon precursor cultures.
Formal Description
Interaction-ID: 4295

gene/protein

GSK3B

decreases_activity of

in ventral mesencephalon
Drugbank entries Show/Hide entries for GSK3B
Comment Kenpaullone is a GSK-3beta specific inhibitor. Addition of kenpaullone increased the percentage of dopaminergic neurons.
Formal Description
Interaction-ID: 4296

drug/chemical compound

Kenpaullone

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Kenpaullone is a GSK-3beta specific inhibitor. Addition of kenpaullone increased the percentage of dopaminergic neurons.
Formal Description
Interaction-ID: 4335

drug/chemical compound

Kenpaullone

decreases_activity of

in ventral mesencephalon
Comment Treatment of ventral mesencephalon precursors with kenpaullone led to a downregulation of GSK-3beta protein levels.
Formal Description
Interaction-ID: 4336

drug/chemical compound

Kenpaullone

decreases_quantity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Treatment of ventral mesencephalon precursors with kenpaullone resulted in increased mRNA levels of the protooncogene c-ret.
Formal Description
Interaction-ID: 4348

drug/chemical compound

Kenpaullone

increases_expression of

gene/protein

RET

Drugbank entries Show/Hide entries for RET
Comment Treatment of ventral mesencephalon precursors with kenpaullone resulted in increased levels of beta-catenin protein, indicating increased stabilization of beta-catenin upon treatment with the inhibitor.
Formal Description
Interaction-ID: 4349

drug/chemical compound

Kenpaullone

increases_quantity of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Beta-catenin stabilization increases the differentiation of ventral mesencephalon precursors into DA neurons.
Formal Description
Interaction-ID: 4350

gene/protein

CTNNB1

affects_activity of

in ventral mesencephalon
Drugbank entries Show/Hide entries for CTNNB1