General Information:

Id: 7,522 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Mammalia
review
Reference: Raber J(2008) AR, apoE, and cognitive function Horm Behav 53: 706-715 [PMID: 18395206]

Interaction Information:

Comment In the vertical limb of the diagonal band of Broca, a major cholinergic nucleus in the basal forebrain affected in AD, the presence of AD pathology or an ε4 allele negatively correlates with the percentage of AR-positive neurons in women, but not in men.
Formal Description
Interaction-ID: 74196

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

tissue/cell line

AR-positive neurons

in female