General Information:

Id: 7,522 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Mammalia
review
Reference: Raber J(2008) AR, apoE, and cognitive function Horm Behav 53: 706-715 [PMID: 18395206]

Interaction Information:

Comment At 6 months of age, apoE4 female showed impairments in hippocampus-dependent spatial learning and memory in the water maze. These impairments were observed in mice that express apoE4 in neurons or astrocytes and are therefore independent of the cellular source of apoE. They require apoE4 and are not seen in Apoe-/- female mice, consistent with a pathogenic gain of function of apoE4.
Formal Description
Interaction-ID: 74174

gene/protein mutant

APOE (isoform E4)

decreases_activity of

process

spartial memory

in APOA4 female mice
Comment At 6 months of age, apoE4 female showed impairments in hippocampus-dependent spatial learning and memory in the water maze. These impairments were observed in mice that express apoE4 in neurons or astrocytes and are therefore independent of the cellular source of apoE. They require apoE4 and are not seen in Apoe-/- female mice, consistent with a pathogenic gain of function of apoE4.
Formal Description
Interaction-ID: 74176

gene/protein mutant

APOE (isoform E4)

decreases_activity of

process

memory

in APOA4 female mice
Comment Compared to age-matched wild-type and Apoe-/- mice, expression of apoE4, but not apoE3, reduces cytosolic AR binding to androgens in the neocortex of female and male mice
Formal Description
Interaction-ID: 74185

gene/protein mutant

APOE (isoform E4)

decreases_activity of

gene/protein

AR

Drugbank entries Show/Hide entries for AR
Comment In cortical extracts, more AR was pulled down from extracts of NSE-apoE4 than NSE-apoE3 mice. GST-apoE proteins pull down ARs from cortical extracts of Apoe−/− mice and that GST-apoE4 might pull down more ARs than GST-apoE3 or GST-apoE2.
Formal Description
Interaction-ID: 74190

gene/protein mutant

APOE (isoform E4)

interacts (colocalizes) with

gene/protein

AR

in cortical extracts; in Apo-/- mice
Drugbank entries Show/Hide entries for AR
Comment In the vertical limb of the diagonal band of Broca, a major cholinergic nucleus in the basal forebrain affected in AD, the presence of AD pathology or an ε4 allele negatively correlates with the percentage of AR-positive neurons in women, but not in men.
Formal Description
Interaction-ID: 74196

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

tissue/cell line

AR-positive neurons

in female
Comment In the vertical limb of the diagonal band of Broca, a major cholinergic nucleus in the basal forebrain affected in AD, the presence of AD pathology or an ε4 allele negatively correlates with the percentage of AR-positive neurons in women, but not in men.
Formal Description
Interaction-ID: 74197

gene/protein mutant

APOE (isoform E4)

NOT affects_quantity of

tissue/cell line

AR-positive neurons

in male