General Information:

Id: 742
Diseases: Alzheimer disease - [OMIM]
Mus musculus
immortalized Aph-1a-/- fibroblasts
article
Reference: Ma G et al.(2005) APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J. Neurosci. 25: 192-198 [PMID: 15634781]

Interaction Information:

Comment APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. Deletion of Aph-1a resulted in significant reduction in levels of high-molecular-weight gamma-secretase complex and secretion of beta-amyloid (Abeta).
Formal Description
Interaction-ID: 4180

gene/protein

APH1A

affects_quantity of

Comment APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. Deletion of Aph-1a resulted in significant reduction in levels of high-molecular-weight gamma-secretase complex and secretion of beta-amyloid (Abeta).
Formal Description
Interaction-ID: 4184

gene/protein

APH1A

affects_quantity of

gene/protein

Amyloid beta peptide