General Information:

Id: 741
Diseases: Neurological
Mus musculus
BTO:0003058 NB2a/d1 cell
article
Reference: Ciani L and Salinas PC(2007) c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability. BMC Cell Biol. 8: 27 [PMID: 17608927]

Interaction Information:

Comment The Wnt signalling pathway has been shown to directly regulate the cytoskeletal network by regulating both the dynamics and organization of microtubules.
Formal Description
Interaction-ID: 4160

affects_activity of

Comment Binding of Wnt proteins to their Frizzled receptors activates the cytoplasmic scaffold protein Dvl.
Formal Description
Interaction-ID: 4161

affects_activity of

gene/protein

DVL

Comment Dishevelled (DVL) binds to and stabilises microtubules through inhibition of Gsk3beta and a second signalling pathway.
Formal Description
Interaction-ID: 4162

gene/protein

DVL

interacts (colocalizes) with

cellular component

microtubule

Comment Dishevelled (DVL) binds to and stabilises microtubules through inhibition of Gsk3beta and a second signalling pathway.
Formal Description
Interaction-ID: 4163

gene/protein

DVL

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Dishevelled (DVL) binds to and stabilises microtubules through inhibition of Gsk3beta and a second signalling pathway.
Formal Description
Interaction-ID: 4164

gene/protein

GSK3B

affects_activity of

Drugbank entries Show/Hide entries for GSK3B
Comment Dvl regulates MT stability through a Rho-independent pathway.
Formal Description
Interaction-ID: 4165

gene/protein

RHOA

NOT affects_activity of

gene/protein

DVL

Drugbank entries Show/Hide entries for RHOA
Comment Rac1 is not required for the regulation of MT dynamics by Dvl.
Formal Description
Interaction-ID: 4167

gene/protein

RAC1

NOT affects_activity of

gene/protein

DVL

Drugbank entries Show/Hide entries for RAC1
Comment Cdc42 is not required by Dvl to regulate MT dynamics.
Formal Description
Interaction-ID: 4168

gene/protein

CDC42

NOT affects_activity of

gene/protein

DVL

Drugbank entries Show/Hide entries for CDC42
Comment Anisomycin is a direct activator of JNK when used in low concentrations.
Formal Description
Interaction-ID: 4182

drug/chemical compound

Anisomycin

increases_activity of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for Anisomycin or MAPK8
Comment Expression of full-length JNK increases microtubule stability.
Formal Description
Interaction-ID: 4183

gene/protein

MAPK8

increases_activity of

Drugbank entries Show/Hide entries for MAPK8
Comment Inhibition of the JNK pathway blocks Dvl function on MT stability.
Formal Description
Interaction-ID: 4185

process

JNK cascade

increases_activity of

gene/protein

DVL

Comment JNK phosphorylates c-JUN.
Formal Description
Interaction-ID: 4186

gene/protein

MAPK8

increases_phosphorylation of

gene/protein

JUN

Drugbank entries Show/Hide entries for MAPK8 or JUN
Comment DVL activates JNK.
Formal Description
Interaction-ID: 4187

gene/protein

DVL

increases_activity of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for MAPK8
Comment Increased microtubule stability by Dvl is achieved through inhibition of Gsk3beta and activation of JNK and that the two pathways are acting independently to regulate the microtubule cytoskeleton.
Formal Description
Interaction-ID: 4188

gene/protein

MAPK8

increases_activity of

Drugbank entries Show/Hide entries for MAPK8
Comment Increased microtubule stability by Dvl is achieved through inhibition of Gsk3beta and activation of JNK and that the two pathways are acting independently to regulate the microtubule cytoskeleton.
Formal Description
Interaction-ID: 4189

gene/protein

GSK3B

affects_activity of

Drugbank entries Show/Hide entries for GSK3B
Comment Increased microtubule stability by Dvl is achieved through inhibition of Gsk3beta and activation of JNK and that the two pathways are acting independently to regulate the microtubule cytoskeleton.
Formal Description
Interaction-ID: 4195

process

JNK cascade

increases_activity of