General Information:

Id: 738 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0001620 SK-N-SH cell
article
Reference: Yamagishi S et al.(2007) An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation PLoS ONE 2: E1030 [PMID: 17925878]

Interaction Information:

Comment ER stress promotes the aggregation of mutant SOD1 and is involved in the development of LBHI/Ast-HI (Lewy body-like hyaline inclusions/astrocytic hyaline inclusions) in patients with mutant SOD1 linked FALS.
Formal Description
Interaction-ID: 13355

process

response to endoplasmic reticulum stress

increases_quantity of

phenotype

SOD1 protein aggregates

in mutant SOD1L84V mice