General Information:

Id: 737 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0001009 PC-12 cell
Reference: Rodriguez-Blanco J et al.(2008) Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine. J. Neurochem. 107: 127-140 [PMID: 18665912]

Interaction Information:

Comment Production of free radicals in the cells is significantly increased after 2h treatment with 6-OHDA. Besides the increase in intracellular oxidants, 6-OHDA also causes mitochondrial function impairment and DNA damage. Altogether, these events induce loss of mitochondrial potential, cytochrome c release and initiation of the apoptotic process.
Formal Description
Interaction-ID: 4127

drug/chemical compound


increases_quantity of

drug/chemical compound

Reactive oxygen species