General Information:

Id: 736 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Lipodystrophy
Majeed syndrome - [OMIM]
Obesity - [OMIM]
Mammalia
review
Reference: Reue K and Zhang P(2008) The lipin protein family: dual roles in lipid biosynthesis and gene expression FEBS Lett. 1: 90-96 [PMID: 18023282]

Interaction Information:

Comment Lipin-1 plays a role in activation of fatty acid oxidation genes during fasting. This occurs through direct interaction of lipin-1 with PGC-1alpha and PPAR alpha, leading to the formation of a complex that modulates gene transcription.
Formal Description
Interaction-ID: 4301

gene/protein

LPIN1

decreases_activity of

during fasting, via interaction of LPIN1 with PGC1A and PPARA