General Information:

Id: 732 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Dentin R et al.(2006) Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBP. J. Nutr. 136: 1145-1149 [PMID: 16614395]

Interaction Information:

Comment Dietary fat regulates hepatic gene expression by controlling the activity or abundance of several key transcription factors, including peroxisome proliferator-activated receptors (PPAR-alpha, beta, gamma-1, and gamma-2) , hepatic nuclear factors (HNF-4-alpha), retinoid X receptor (RXR-alpha), liver X receptor (LXR-alpha), and SREBP-1c.
Formal Description
Interaction-ID: 4113

environment

dietary fat

affects_activity of

gene/protein

PPARA

in liver
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