General Information:

Id: 7,322 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Mielke MM et al.(2014) Clinical epidemiology of Alzheimers disease: assessing sex and gender differences Clin Epidemiol 6: 37-48 [PMID: 24470773]

Interaction Information:

Comment The E4 allele of the apolipoprotein E (APOE) gene is the strongest known genetic risk factor for late-onset AD. Compared to non-carriers, heterozygous carriers of one E4 allele are 3–4 times more likely to develop AD, whereas the risk for homozygous carriers is even higher. The APOE E4 allele is specifically associated with an earlier age of onset of AD.
Formal Description
Interaction-ID: 71967

gene/protein mutant

APOE (isoform E4)

increases_activity of

Comment The effects of the E4 genotype are more pronounced in women than in men. Three studies reported that women with one E4 allele had about a four-fold risk of AD, whereas men with one E4 allele showed little increased risk.
Formal Description
Interaction-ID: 71968

phenotype

sex, female

increases_activity of

gene/protein mutant

APOE (isoform E4)

concerning AD in women
Comment The APOE E4 allele has a greater deleterious effect on hippocampal pathology, functional connectivity changes in the default mode network, cortical thickness, and memory performance in women compared with men at different stages of AD.
Formal Description
Interaction-ID: 71969

gene/protein mutant

APOE (isoform E4)

decreases_activity of

tissue/cell line

hippocampus

depending on sex: worse in women compared with men at different stages of AD.
Comment The APOE E4 allele has a greater deleterious effect on hippocampal pathology, functional connectivity changes in the default mode network, cortical thickness, and memory performance in women compared with men at different stages of AD.
Formal Description
Interaction-ID: 71970

gene/protein mutant

APOE (isoform E4)

affects_activity of

tissue/cell line

brain

Comment The APOE E4 allele has a greater deleterious effect on hippocampal pathology, functional connectivity changes in the default mode network, cortical thickness, and memory performance in women compared with men at different stages of AD.
Formal Description
Interaction-ID: 71971

gene/protein mutant

APOE (isoform E4)

decreases_activity of

process

memory

depending on sex: worse in women compared with men at different stages of AD.
Comment A large autopsy study found that amyloid plaque and neurofibrillary tangle pathology was greatest among women who were E4 carriers.
Formal Description
Interaction-ID: 71972

gene/protein mutant

APOE (isoform E4)

increases_quantity of

especially in women who were E4 carriers.
Comment A large autopsy study found that amyloid plaque and neurofibrillary tangle pathology was greatest among women who were E4 carriers.
Formal Description
Interaction-ID: 71973

gene/protein mutant

APOE (isoform E4)

increases_quantity of

especially in women who were E4 carriers.
Comment The effects of the E4 genotype are more pronounced in women than in men. Three studies reported that women with one E4 allele had about a four-fold risk of AD, whereas men with one E4 allele showed little increased risk.
Formal Description
Interaction-ID: 72092

gene/protein mutant

APOE (isoform E4)

increases_activity of

concerning AD in women.
Comment The effects of the E4 genotype are more pronounced in women than in men. Three studies reported that women with one E4 allele had about a four-fold risk of AD, whereas men with one E4 allele showed little increased risk.
Formal Description
Interaction-ID: 124712

phenotype

sex, male

decreases_activity of

gene/protein mutant

APOE (isoform E4)

in men; concerning AD, compared to women