General Information:

Id: 7,322 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Mielke MM et al.(2014) Clinical epidemiology of Alzheimers disease: assessing sex and gender differences Clin Epidemiol 6: 37-48 [PMID: 24470773]

Interaction Information:

Comment The APOE E4 allele has a greater deleterious effect on hippocampal pathology, functional connectivity changes in the default mode network, cortical thickness, and memory performance in women compared with men at different stages of AD.
Formal Description
Interaction-ID: 71969

gene/protein mutant

APOE (isoform E4)

decreases_activity of

tissue/cell line

hippocampus

depending on sex: worse in women compared with men at different stages of AD.