General Information:

Id: 7,250 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
HEK293 cells; ES-cell-derived human neurons
article
Reference: Huang YA et al.(2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion Cell 168: 427-441.e21 [PMID: 28111074]

Interaction Information:

Comment ApoE increases APP expression 3-4-fold with an ApoE4>ApoE3>ApoE2 potency rank order by activating the DLK-> MKK7 -> ERK1/2 MAP-kinase pathway.
Formal Description
Interaction-ID: 71302

gene/protein mutant

APOE (isoform E4)

increases_expression of

gene/protein

APP

in human neurons; compared to ApoE3 and ApoE2
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