General Information:

Id: 7,225
Diseases: Metabolic
Homo sapiens
keratinocyte HaCaT cell
article
Reference: Suzuki H et al.(2004) c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements Oncogene 23: 5068-5076 [PMID: 15107821]

Interaction Information:

Comment TGF-beta signaling reduces the expression of c-myc mRNA.
Formal Description
Interaction-ID: 71112

decreases_expression of

gene/protein

MYC

Comment Ski inhibits the TGF-beta-induced downregulation of c-myc promoter activity. In addition, Ski also blocks the TGF-beta-induced transcriptional activation. In cells transfected with Ski, the binding of SMAD2 and SMAD4 to the DNA is enhanced.
Formal Description
Interaction-ID: 71129

gene/protein

SKI

decreases_activity of

by stabilization of inactive Smad complexes on DNA