General Information:

Id: 721 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Drosophila melanogaster
article
Reference: Ng CH et al.(2009) Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. J. Neurosci. 29 [PMID: 19741132]

Interaction Information:

Comment Co-expression of human parkin in LRRK2 G2019S-expressing flies provides significant protection against DA neurodegeneration that occurs with age or in response to rotenone.
Formal Description
Interaction-ID: 4066

gene/protein

PARK2

decreases_activity of

gene/protein mutant

LRRK2-p.G2019S