General Information:

Id: 720
Diseases: Parkinson disease
Drosophila melanogaster
article
Reference: Venderova K et al.(2009) Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinsons disease. Hum. Mol. Genet. 18: 4390-4404 [PMID: 19692353]

Interaction Information:

Comment Loss of dopaminergic neurons after transfection of the flies with LRRK2-I2020T, -R144C or WT-LRRK2.
Formal Description
Interaction-ID: 4053

gene/protein

LRRK2

increases_activity of

process

neuron death

if LRRK2 is overexpressed
Comment Loss of dopaminergic neurons after transfection of the flies with LRRK2-I2020T, -R144C or WT-LRRK2.
Formal Description
Interaction-ID: 4054

gene/protein mutant

LRRK2-p.I2020T

increases_activity of

process

neuron death

Comment Loss of dopaminergic neurons after transfection of the flies with LRRK2-I2020T, -R144C or WT-LRRK2.
Formal Description
Interaction-ID: 4055

gene/protein mutant

LRRK2-p.R144C

increases_activity of

process

neuron death

Comment Chronic exposure of flies expressing hLRRK2 in dopaminergic neurons to low doses of rotenone significantly increased dopaminergic neuron death in these flies, compared with both non-treated hLRRK2 expressing flies, or control rotenone-treated flies.
Formal Description
Interaction-ID: 4056

drug/chemical compound

Rotenone

increases_activity of

process

neuron death

Comment PINK1, Parkin and DJ-1 modify LRRK2-induced phenotypic changes in flies.
Formal Description
Interaction-ID: 4057

gene/protein

PINK1

affects_activity of

gene/protein

LRRK2

Comment PINK1, Parkin and DJ-1 modify LRRK2-induced phenotypic changes in flies.
Formal Description
Interaction-ID: 4058

gene/protein

PARK2

affects_activity of

gene/protein

LRRK2

Comment PINK1, Parkin and DJ-1 modify LRRK2-induced phenotypic changes in flies.
Formal Description
Interaction-ID: 4059

gene/protein

PARK7

affects_activity of

gene/protein

LRRK2

Drugbank entries Show/Hide entries for PARK7