General Information:

Id: 718 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
PDAPP (APPV717F) transgenic mouse
Reference: Su Y et al.(2004) Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing Biochemistry 43: 6899-6908 [PMID: 15170327]

Interaction Information:

Comment Lithium treatment abolished GSK3beta- mediated Abeta increase in the brains of GSK3beta transgenics and reduced plaque burden in the brains of the PDAPP (APPV717F) transgenic mice.
Formal Description
Interaction-ID: 4028

drug/chemical compound


decreases_quantity of

in hippocampus
Drugbank entries Show/Hide entries for Lithium