General Information:

Id: 718 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
PDAPP (APPV717F) transgenic mouse
brain
article
Reference: Su Y et al.(2004) Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing Biochemistry 43: 6899-6908 [PMID: 15170327]

Interaction Information:

Comment Lithium regulates amyloid-beta precursor protein (APP) processing.
Formal Description
Interaction-ID: 4013

drug/chemical compound

Lithium

affects_processing of

gene/protein

APP

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Comment Lithium lowers the amyloid-beta (40, 42) peptide production.
Formal Description
Interaction-ID: 4018

drug/chemical compound

Lithium

decreases_quantity of

Drugbank entries Show/Hide entries for Lithium
Comment Lithium treatment abolished GSK3beta- mediated Abeta increase in the brains of GSK3beta transgenics and reduced plaque burden in the brains of the PDAPP (APPV717F) transgenic mice.
Formal Description
Interaction-ID: 4028

drug/chemical compound

Lithium

decreases_quantity of

in hippocampus
Drugbank entries Show/Hide entries for Lithium
Comment Lithium lowers the amyloid-beta (40, 42) peptide production.
Formal Description
Interaction-ID: 5839

drug/chemical compound

Lithium

decreases_quantity of

Drugbank entries Show/Hide entries for Lithium