General Information:

Id: 7,173 (click here to show other Interactions for entry)
Diseases: Cancer
Ciliopathy
Nephronophthisis
Mammalia
review
Reference: [PMID: 26045258]

Interaction Information:

Comment It remains to be determined whether YAP/TAZ-mediated, TGFbeta-dependent transcription is regulated exclusively via SMADs or whether it may also require TEADs or context-dependent partnering with diverse transcription factors.
Formal Description
Interaction-ID: 70716

affects_activity of

gene/protein

YAP1

Comment It remains to be determined whether YAP/TAZ-mediated, TGFbeta-dependent transcription is regulated exclusively via SMADs or whether it may also require TEADs or context-dependent partnering with diverse transcription factors.
Formal Description
Interaction-ID: 70717

affects_activity of

gene/protein

WWTR1

Comment Integrin-linked kinase, an integrin-associated actin and tubulin cytoskeleton-interacting effector that mediates TGFbeta signaling, was found to be a negative regulator of the Hippo kinase cascade in cancer cells by inhibiting MYPT1, which leads to inhibition of NF2 and nuclear accumulation of YAP/TAZ.
Formal Description
Interaction-ID: 70719

gene/protein

ILK

increases_activity of