General Information:

Id: 7,172 (click here to show other Interactions for entry)
Diseases: Acrocallosal syndrome - [OMIM]
Joubert syndrome
Short-rib thoracic dysplasia 3 with or without polydactyly - [OMIM]
Mammalia
review
Reference: [PMID: 27765513]

Interaction Information:

Comment The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis.
Formal Description
Interaction-ID: 70417
Comment The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis.
Formal Description
Interaction-ID: 70596

affects_activity of

phenotype

neoplasm

Comment The mammalian Hedgehog (Hh) pathway depends on primary cilia and intraflagellar trafficking.
Formal Description
Interaction-ID: 70597

cellular component

cilium

increases_activity of

Comment The mammalian Hedgehog (Hh) pathway depends on primary cilia and intraflagellar trafficking.
Formal Description
Interaction-ID: 70598

increases_activity of

Comment The Hh signaling pathway (and therefore primary cilia) is responsible for many aspects of vertebrate embryonic development.
Formal Description
Interaction-ID: 70599
Comment KIF3A is required for ciliary formation and Hh signaling in every cell type tested in mice.
Formal Description
Interaction-ID: 70607

gene/protein

KIF3A

increases_activity of

Comment In all mouse Dync2h1 alleles analyzed, Shh signaling is reduced in the neural tube and mutants lack the floor plate and V3 progenitors, which are specified by the highest level of Shh activity.
Formal Description
Interaction-ID: 70631

gene/protein

DYNC2H1

affects_activity of