CIDeRGeneral Information:
| Id: | 7,172 (click here to show other Interactions for entry) |
| Diseases: |
Acrocallosal syndrome
- [OMIM]
Joubert syndrome Short-rib thoracic dysplasia 3 with or without polydactyly - [OMIM] |
| Mammalia | |
| review | |
| Reference: | [PMID: 27765513] |
Interaction Information:
| Comment | The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis. |
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Formal Description Interaction-ID: 70417 |
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| Comment | The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis. |
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Formal Description Interaction-ID: 70596 |
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| Comment | The mammalian Hedgehog (Hh) pathway depends on primary cilia and intraflagellar trafficking. |
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Formal Description Interaction-ID: 70597 |
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| Comment | The mammalian Hedgehog (Hh) pathway depends on primary cilia and intraflagellar trafficking. |
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Formal Description Interaction-ID: 70598 |
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| Comment | The Hh signaling pathway (and therefore primary cilia) is responsible for many aspects of vertebrate embryonic development. |
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Formal Description Interaction-ID: 70599 |
process affects_activity of |
| Comment | KIF3A is required for ciliary formation and Hh signaling in every cell type tested in mice. |
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Formal Description Interaction-ID: 70607 |
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| Comment | In all mouse Dync2h1 alleles analyzed, Shh signaling is reduced in the neural tube and mutants lack the floor plate and V3 progenitors, which are specified by the highest level of Shh activity. |
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Formal Description Interaction-ID: 70631 |
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