General Information:

Id: 7,171
Diseases: Nephronophthisis 19 - [OMIM]
Rattus norvegicus
article
Reference: [PMID: 21698230]

Interaction Information:

Comment Dcdc2 protein localizes to the primary cilium in primary rat hippocampal neurons and it can be found within close proximity to the ciliary kinesin-2 subunit Kif3a.
Formal Description
Interaction-ID: 70416

gene/protein

DCDC2

is localized in

cellular component

cilium

in hippocampal neurons
Comment Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 expression enhances Wnt signaling, consistent with a functional role in ciliary signaling.
Formal Description
Interaction-ID: 70586

gene/protein

DCDC2

increases_activity of

process

cilium elongation

Comment Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 expression enhances Wnt signaling, consistent with a functional role in ciliary signaling.
Formal Description
Interaction-ID: 70587

gene/protein

DCDC2

affects_activity of

Comment Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 expression enhances Wnt signaling, consistent with a functional role in ciliary signaling.
Formal Description
Interaction-ID: 70588

gene/protein

DCDC2

affects_activity of

Comment Lysates from rat primary hippocampal neurons were pulled down with an antibody against DCDC2. Probing with Kif3a antibody revealed that Kif3a could be precipitated together with Dcdc2.
Formal Description
Interaction-ID: 70589

gene/protein

DCDC2

interacts (colocalizes) with

gene/protein

KIF3A

in hippocampal neurons
Comment Key microarray results were further confirmed by quantitative real-time PCR (qRT-PCR). For the verification, five genes were selected: Pdgfra which was the most upregulated gene, Cdc2 which is involved in the same pathway as Pdgfra, two kinesin family genes Kif4 and Kif2c, and Hhip that is involved in Sonic Hedgehog signaling. Changes in gene expression measured by qRT-PCR were fully consistent with the data obtained by microarray analysis.
Formal Description
Interaction-ID: 70591

gene/protein

DCDC2

increases_expression of

gene/protein

PDGFRA

Drugbank entries Show/Hide entries for PDGFRA
Comment Key microarray results were further confirmed by quantitative real-time PCR (qRT-PCR). For the verification, five genes were selected: Pdgfra which was the most upregulated gene, Cdc2 which is involved in the same pathway as Pdgfra, two kinesin family genes Kif4 and Kif2c, and Hhip that is involved in Sonic Hedgehog signaling. Changes in gene expression measured by qRT-PCR were fully consistent with the data obtained by microarray analysis.
Formal Description
Interaction-ID: 70592

gene/protein

DCDC2

increases_expression of

gene/protein

CDK1

Drugbank entries Show/Hide entries for CDK1
Comment Key microarray results were further confirmed by quantitative real-time PCR (qRT-PCR). For the verification, five genes were selected: Pdgfra which was the most upregulated gene, Cdc2 which is involved in the same pathway as Pdgfra, two kinesin family genes Kif4 and Kif2c, and Hhip that is involved in Sonic Hedgehog signaling. Changes in gene expression measured by qRT-PCR were fully consistent with the data obtained by microarray analysis.
Formal Description
Interaction-ID: 70593

gene/protein

DCDC2

increases_expression of

gene/protein

KIF4A

Comment Key microarray results were further confirmed by quantitative real-time PCR (qRT-PCR). For the verification, five genes were selected: Pdgfra which was the most upregulated gene, Cdc2 which is involved in the same pathway as Pdgfra, two kinesin family genes Kif4 and Kif2c, and Hhip that is involved in Sonic Hedgehog signaling. Changes in gene expression measured by qRT-PCR were fully consistent with the data obtained by microarray analysis.
Formal Description
Interaction-ID: 70594

gene/protein

DCDC2

increases_expression of

gene/protein

KIF2C

Drugbank entries Show/Hide entries for KIF2C
Comment Key microarray results were further confirmed by quantitative real-time PCR (qRT-PCR). For the verification, five genes were selected: Pdgfra which was the most upregulated gene, Cdc2 which is involved in the same pathway as Pdgfra, two kinesin family genes Kif4 and Kif2c, and Hhip that is involved in Sonic Hedgehog signaling. Changes in gene expression measured by qRT-PCR were fully consistent with the data obtained by microarray analysis.
Formal Description
Interaction-ID: 70595

gene/protein

DCDC2

increases_expression of

gene/protein

HHIP