General Information:

Id: 7,168
Diseases: Nephronophthisis 15 - [OMIM]
Mus musculus
article
Reference: [PMID: 23955340]

Interaction Information:

Comment The primary cilium is required for Hedgehog signaling. Mouse DZIP1 regulates Hedgehog signaling through two mechanisms. First, DZIP1 interacts with GLI3, a transcriptional regulator for Hedgehog signaling, and prevents GLI3 from entering the nucleus. Second, DZIP1 is required for ciliogenesis.
Formal Description
Interaction-ID: 70413

gene/protein

DZIP1

interacts (colocalizes) with

gene/protein

GLI3

Comment The primary cilium is required for Hedgehog signaling. Mouse DZIP1 regulates Hedgehog signaling through two mechanisms. First, DZIP1 interacts with GLI3, a transcriptional regulator for Hedgehog signaling, and prevents GLI3 from entering the nucleus. Second, DZIP1 is required for ciliogenesis.
Formal Description
Interaction-ID: 70555

gene/protein

DZIP1

decreases_quantity of

gene/protein

GLI3

in the nucleus
Comment The primary cilium is required for Hedgehog signaling. Mouse DZIP1 regulates Hedgehog signaling through two mechanisms. First, DZIP1 interacts with GLI3, a transcriptional regulator for Hedgehog signaling, and prevents GLI3 from entering the nucleus. Second, DZIP1 is required for ciliogenesis.
Formal Description
Interaction-ID: 70556

gene/protein

DZIP1

increases_activity of

process

cilium assembly

Comment DZIP1 colocalizes and interacts with CEP164, a protein localizing at appendages of the mother centrioles, and IFT88, a component of the intraflagellar transport (IFT) machinery.
Formal Description
Interaction-ID: 70557

gene/protein

DZIP1

interacts (colocalizes) with

gene/protein

CEP164

Comment DZIP1 colocalizes and interacts with CEP164, a protein localizing at appendages of the mother centrioles, and IFT88, a component of the intraflagellar transport (IFT) machinery.
Formal Description
Interaction-ID: 70558

gene/protein

DZIP1

interacts (colocalizes) with

gene/protein

IFT88

Comment DZIP1 localizes to the basal body and is required for ciliogenesis.
Formal Description
Interaction-ID: 70559

gene/protein

DZIP1

is localized in

cellular component

ciliary basal body

Comment DZIP1 is required for the localization of CEP164 and ninein to the appendages of the mother centrioles.
Formal Description
Interaction-ID: 70560

gene/protein

DZIP1

increases_quantity of

gene/protein

CEP164

at the distal appendages of the mother centrioles
Comment DZIP1 is required for the localization of CEP164 and ninein to the appendages of the mother centrioles.
Formal Description
Interaction-ID: 70561

gene/protein

DZIP1

increases_quantity of

gene/protein

NIN

at the subdistal appendages of the mother centrioles
Comment DZIP1 is the first known cilia-related protein that regulates Hedgehog signaling through a dual mechanism, by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.
Formal Description
Interaction-ID: 70562

gene/protein

DZIP1

affects_activity of