General Information:

Id: 7,164
Diseases: COACH syndrome - [OMIM]
Joubert syndrome 6 - [OMIM]
Meckel syndrome, type 3 - [OMIM]
Nephronophthisis 11 - [OMIM]
Mus musculus
article
Reference: [PMID: 26035863]

Interaction Information:

Comment TMEM67 (meckelin) is essential for phosphorylation of the non-canonical Wnt receptor ROR2 (receptor-tyrosine-kinase-like orphan receptor 2) upon stimulation with Wnt5a-conditioned medium. ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone.
Formal Description
Interaction-ID: 70409

gene/protein

TMEM67

increases_phosphorylation of

gene/protein

ROR2

Comment TMEM67 (meckelin) is essential for phosphorylation of the non-canonical Wnt receptor ROR2 (receptor-tyrosine-kinase-like orphan receptor 2) upon stimulation with Wnt5a-conditioned medium. ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone.
Formal Description
Interaction-ID: 70525

gene/protein

TMEM67

interacts (colocalizes) with

gene/protein

ROR2

at the ciliary transition zone
Comment The extracellular N-terminal domain of TMEM67 preferentially binds to Wnt5a in an in vitro binding assay.
Formal Description
Interaction-ID: 70526

gene/protein

TMEM67

interacts (colocalizes) with

gene/protein

WNT5A

Comment Wnt5a inhibited both the Shh and canonical Wnt/beta-catenin signalling pathways in wild-type embryonic lung.
Formal Description
Interaction-ID: 70527

gene/protein

WNT5A

decreases_activity of

in embryonic lung
Comment Wnt5a inhibited both the Shh and canonical Wnt/beta-catenin signalling pathways in wild-type embryonic lung.
Formal Description
Interaction-ID: 70528

gene/protein

WNT5A

decreases_activity of

in embryonic lung
Comment TMEM67 is a receptor that has a main role in non-canonical Wnt signalling, mediated by Wnt5a and ROR2, and normally represses Shh signalling.
Formal Description
Interaction-ID: 70529

gene/protein

TMEM67

increases_activity of