General Information:

Id: 715 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
parkin -/- mouse
article
Reference: Rawal N et al.(2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem. Biophys. Res. Commun. 388: 473-478 [PMID: 19591802]

Interaction Information:

Comment Loss of Parkin renders DA neurons more vulnerable to excessive Wnt/beta-catenin signaling and suggest that Parkin acts to protect DA neurons from Wnt/beta-catenin signaling by targeting beta-catenin for degradation.
Formal Description
Interaction-ID: 3985

gene/protein

PRKN

affects_activity of

process

canonical Wnt signaling pathway

in ventral midbrain dopaminergic neurons