General Information:

Id: 715 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
parkin -/- mouse
article
Reference: Rawal N et al.(2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem. Biophys. Res. Commun. 388: 473-478 [PMID: 19591802]

Interaction Information:

Comment Expression levels of beta-catenin were significantly higher in parkin null mice compared to wt controls. This difference appeared specific to the ventral midbrain, where DA cell bodies reside, since regions such as cerebellum or striatum did not exhibit changes.
Formal Description
Interaction-ID: 3975

gene/protein

PARK2

decreases_quantity of

gene/protein

CTNNB1

in ventral midbrain dopaminergic neurons
Drugbank entries Show/Hide entries for CTNNB1