General Information:

Id: 7,157 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephronophthisis 7 - [OMIM]
Mammalia
review
Reference: [PMID: 22391303]

Interaction Information:

Comment SUFU restrains Gli3 in the cytoplasm, promoting its processing into a repressor, while initiation of hedgehog signaling triggers the dissociation of SUFU and promotes the translocation of the activated form into the nucleus.
Formal Description
Interaction-ID: 70442

process

smoothened signaling pathway

increases_transport of

gene/protein

GLI3

into the nucleus
Comment Activation of Hh signaling induced Pdx1-dependent insulin expression and the expression of insulin was decreased in pancreas-specific Smo-null mice.
Formal Description
Interaction-ID: 70477

process

smoothened signaling pathway

increases_expression of

gene/protein

INS

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