General Information:

Id: 7,156
Diseases: Nephronophthisis 7 - [OMIM]
Mus musculus
article
Reference: [PMID: 21816948]

Interaction Information:

Comment Glis2 is a functional component of Hh signaling and is necessary to suppress this pathway in the postnatal kidney.
Formal Description
Interaction-ID: 70401

gene/protein

GLIS2

decreases_activity of

in postnatal kidney
Comment Glis2 inhibits Gli1 activity in cultured renal epithelial cells in the postnatal kidney.
Formal Description
Interaction-ID: 70426

gene/protein

GLIS2

decreases_activity of

gene/protein

GLIS1

Comment Glis2 maintains the differentiated epithelial phenotype by inhibiting the epithelial-to-mesenchymal inducer Snai1.
Formal Description
Interaction-ID: 70427

gene/protein

GLIS2

decreases_activity of

gene/protein

SNAI1

Comment Glis2 maintains the differentiated epithelial phenotype by inhibiting the epithelial-to-mesenchymal inducer Snai1.
Formal Description
Interaction-ID: 70428

gene/protein

GLIS2

decreases_activity of

Comment Glis2 represses the hedgehog-dependent expression of the developmental gene Wnt4.
Formal Description
Interaction-ID: 70429

gene/protein

GLIS2

decreases_expression of

gene/protein

WNT4