General Information:

Id: 715
Diseases: Parkinson disease
Mus musculus
parkin -/- mouse
article
Reference: Rawal N et al.(2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem. Biophys. Res. Commun. 388: 473-478 [PMID: 19591802]

Interaction Information:

Comment Expression levels of beta-catenin were significantly higher in parkin null mice compared to wt controls. This difference appeared specific to the ventral midbrain, where DA cell bodies reside, since regions such as cerebellum or striatum did not exhibit changes.
Formal Description
Interaction-ID: 3975

gene/protein

PARK2

decreases_quantity of

gene/protein

CTNNB1

in ventral midbrain dopaminergic neurons
Drugbank entries Show/Hide entries for CTNNB1
Comment Beta-catenin mRNA levels were not significantly altered in parkin null ventral midbrain, indicating that accumulation of beta-catenin is possibly due to impaired degradation of beta-catenin protein.
Formal Description
Interaction-ID: 3979

gene/protein

PARK2

NOT affects_expression of

gene/protein

CTNNB1

in ventral midbrain dopaminergic neurons
Drugbank entries Show/Hide entries for CTNNB1
Comment Loss of Parkin renders DA neurons more vulnerable to excessive Wnt/beta-catenin signaling and suggest that Parkin acts to protect DA neurons from Wnt/beta-catenin signaling by targeting beta-catenin for degradation.
Formal Description
Interaction-ID: 3985

gene/protein

PARK2

affects_activity of

in ventral midbrain dopaminergic neurons
Comment Loss of Parkin renders DA neurons more vulnerable to excessive Wnt/beta-catenin signaling and suggest that Parkin acts to protect DA neurons from Wnt/beta-catenin signaling by targeting beta-catenin for degradation.
Formal Description
Interaction-ID: 3987

gene/protein

PARK2

decreases_quantity of

gene/protein

CTNNB1

in ventral midbrain dopaminergic neurons
Drugbank entries Show/Hide entries for CTNNB1
Comment Loss of Parkin renders DA neurons more vulnerable to excessive Wnt/beta-catenin signaling and suggest that Parkin acts to protect DA neurons from Wnt/beta-catenin signaling by targeting beta-catenin for degradation.
Formal Description
Interaction-ID: 3988

gene/protein

PARK2

decreases_activity of

process

neuron death

in ventral midbrain dopaminergic neurons