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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
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Multiple sclerosis
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Neutropenia, severe congenital
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Postpartum depression
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	Field	Term

General Information:

Id:	714 (click here to show other Interactions for entry)
Diseases:	Abetalipoproteinemia - [OMIM] Cardiovascular disease Diabetes mellitus, type II - [OMIM] Fatty liver disease, nonalcoholic Insulin resistance
Organism:	Mammalia
Publication type:	review
Reference:	Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507]

Interaction Information:

Comment	FoxO1 integrates insulin signaling to hepatic glucose and VLDL production. Hepatic insulin signaling bifurcates at FoxO1 to target different sets of genes in glucose and lipid metabolism. Loss of insulin inhibition of FoxO1 activity in insulin resistant livers results in excessive production of both glucose and VLDL-TG, contributing to the dual pathogenesis of hyperglycemia and hypertriglyceridemia in diabetes.
Formal Description Interaction-ID: 4085	process insulin receptor signaling pathway decreases_activity of gene/protein FOXO1 in liver

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