General Information:

Id: 714 (click here to show other Interactions for entry)
Diseases: Abetalipoproteinemia - [OMIM]
Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mammalia
review
Reference: Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507]

Interaction Information:

Comment FoxO1 mediates the inhibitory effect of insulin on the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), two key enzymes in hepatic gluconeogenesis.
Formal Description
Interaction-ID: 4044

complex/PPI

Insulin

decreases_activity of

process

gluconeogenesis

Comment FoxO1 mediates the inhibitory effect of insulin on the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), two key enzymes in hepatic gluconeogenesis.
Formal Description
Interaction-ID: 4045

gene/protein

G6PC

increases_activity of

process

gluconeogenesis

Comment FoxO1 mediates the inhibitory effect of insulin on the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), two key enzymes in hepatic gluconeogenesis.
Formal Description
Interaction-ID: 4046

gene/protein

PCK1

increases_activity of

process

gluconeogenesis

Drugbank entries Show/Hide entries for PCK1
Comment Under fasting conditions, FoxO1 expression along with its nuclear distribution is increased, accounting for its augmented transcriptional activity to promote hepatic gluconeogenesis. Under fed conditions, FoxO1 is phosphorylated and translocated to the cytoplasm, resulting in inhibition of gluconeogenesis in the liver. These two reciprocal mechanisms play a critical role in maintaining blood glucose levels within a narrow physiological range in different metabolic states.
Formal Description
Interaction-ID: 13068

environment

fasting

increases_activity of

process

gluconeogenesis

via increased nuclear level of FOXO1
Comment Under fasting conditions, FoxO1 expression along with its nuclear distribution is increased, accounting for its augmented transcriptional activity to promote hepatic gluconeogenesis. Under fed conditions, FoxO1 is phosphorylated and translocated to the cytoplasm, resulting in inhibition of gluconeogenesis in the liver. These two reciprocal mechanisms play a critical role in maintaining blood glucose levels within a narrow physiological range in different metabolic states.
Formal Description
Interaction-ID: 13071

environment

feeding

decreases_activity of

process

gluconeogenesis

via increased cytoplasmic level of FOXO1
Comment FoxO1 integrates insulin signaling to hepatic glucose and VLDL production. Hepatic insulin signaling bifurcates at FoxO1 to target different sets of genes in glucose and lipid metabolism. Loss of insulin inhibition of FoxO1 activity in insulin resistant livers results in excessive production of both glucose and VLDL-TG, contributing to the dual pathogenesis of hyperglycemia and hypertriglyceridemia in diabetes.
Formal Description
Interaction-ID: 13072

gene/protein

FOXO1

increases_activity of

process

gluconeogenesis

in liver