CIDeRGeneral Information:
| Id: | 714 (click here to show other Interactions for entry) |
| Diseases: |
Abetalipoproteinemia
- [OMIM]
Cardiovascular disease Diabetes mellitus, type II - [OMIM] Fatty liver disease, nonalcoholic Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507] |
Interaction Information:
| Comment | FoxO1 mediates the inhibitory effect of insulin on the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), two key enzymes in hepatic gluconeogenesis. |
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Formal Description Interaction-ID: 4044 |
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| Comment | FoxO1 mediates the inhibitory effect of insulin on the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), two key enzymes in hepatic gluconeogenesis. |
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Formal Description Interaction-ID: 4045 |
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| Comment | FoxO1 mediates the inhibitory effect of insulin on the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), two key enzymes in hepatic gluconeogenesis. |
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Formal Description Interaction-ID: 4046 |
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| Drugbank entries | Show/Hide entries for PCK1 |
| Comment | Under fasting conditions, FoxO1 expression along with its nuclear distribution is increased, accounting for its augmented transcriptional activity to promote hepatic gluconeogenesis. Under fed conditions, FoxO1 is phosphorylated and translocated to the cytoplasm, resulting in inhibition of gluconeogenesis in the liver. These two reciprocal mechanisms play a critical role in maintaining blood glucose levels within a narrow physiological range in different metabolic states. |
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Formal Description Interaction-ID: 13068 |
environment fasting increases_activity of process |
| Comment | Under fasting conditions, FoxO1 expression along with its nuclear distribution is increased, accounting for its augmented transcriptional activity to promote hepatic gluconeogenesis. Under fed conditions, FoxO1 is phosphorylated and translocated to the cytoplasm, resulting in inhibition of gluconeogenesis in the liver. These two reciprocal mechanisms play a critical role in maintaining blood glucose levels within a narrow physiological range in different metabolic states. |
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Formal Description Interaction-ID: 13071 |
environment feeding decreases_activity of process |
| Comment | FoxO1 integrates insulin signaling to hepatic glucose and VLDL production. Hepatic insulin signaling bifurcates at FoxO1 to target different sets of genes in glucose and lipid metabolism. Loss of insulin inhibition of FoxO1 activity in insulin resistant livers results in excessive production of both glucose and VLDL-TG, contributing to the dual pathogenesis of hyperglycemia and hypertriglyceridemia in diabetes. |
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Formal Description Interaction-ID: 13072 |
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