General Information:
Id: | 714 (click here to show other Interactions for entry) |
Diseases: |
Abetalipoproteinemia
- [OMIM]
Cardiovascular disease Diabetes mellitus, type II - [OMIM] Fatty liver disease, nonalcoholic Insulin resistance |
Mammalia | |
review | |
Reference: | Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507] |
Interaction Information:
Comment | FoxO1 mediates the inhibitory effect of insulin on the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), two key enzymes in hepatic gluconeogenesis. |
Formal Description Interaction-ID: 4044 |
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