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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	714 (click here to show other Interactions for entry)
Diseases:	Abetalipoproteinemia - [OMIM] Cardiovascular disease Diabetes mellitus, type II - [OMIM] Fatty liver disease, nonalcoholic Insulin resistance
Organism:	Mammalia
Publication type:	review
Reference:	Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507]

Interaction Information:

Comment	Increased lipid infiltration into the liver induces ER stress which inhibits hepatic apoB secretion and instigates lipid accumulation, contributing to the development of steatosis.
Formal Description Interaction-ID: 4031	process response to endoplasmic reticulum stress increases_activity of disease Fatty liver disease, nonalcoholic in liver; if ER stress is lipid-induced

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