General Information:

Id: 714 (click here to show other Interactions for entry)
Diseases: Abetalipoproteinemia - [OMIM]
Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mammalia
review
Reference: Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507]

Interaction Information:

Comment Increased lipid infiltration into the liver induces ER stress which inhibits hepatic apoB secretion and instigates lipid accumulation, contributing to the development of steatosis.
Formal Description
Interaction-ID: 4030

decreases_activity of

gene/protein

APOB

in liver; if ER stress is lipid-induced