General Information:

Id: 714 (click here to show other Interactions for entry)
Diseases: Abetalipoproteinemia - [OMIM]
Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mammalia
review
Reference: Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507]

Interaction Information:

Comment Peroxisome proliferator-activated receptor alpha (PPAR-alpha) stimulates hepatic MTP mRNA expression in primary cultures of mouse and rat hepatocytes, however, targeted activation of PPAR-alpha with anti-hypertriglyceridemia therapy such as fibrates helps attenuate hepatic MTP activity in animal models with diet-induced dyslipidemia.
Formal Description
Interaction-ID: 3996

drug/chemical compound

Fibric acid derivative

increases_activity of

gene/protein

PPARA

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