General Information:

Id: 714 (click here to show other Interactions for entry)
Diseases: Abetalipoproteinemia - [OMIM]
Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mammalia
review
Reference: Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507]

Interaction Information:

Comment FoxO1 integrates insulin signaling to hepatic glucose and VLDL production. Hepatic insulin signaling bifurcates at FoxO1 to target different sets of genes in glucose and lipid metabolism. Loss of insulin inhibition of FoxO1 activity in insulin resistant livers results in excessive production of both glucose and VLDL-TG, contributing to the dual pathogenesis of hyperglycemia and hypertriglyceridemia in diabetes.
Formal Description
Interaction-ID: 13072

gene/protein

FOXO1

increases_activity of

process

gluconeogenesis

in liver