General Information:

Id: 713 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A
BTO:0001279 spinal cord
article
Reference: Lee J et al.(2009) Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis FASEB J. 23: 1739-1749 [PMID: 19179380]

Interaction Information:

Comment Oxidative stress up-regulates Bcl-xL mRNA expression in primary astrocytes. The mRNA level of Bcl-xL was increased after 12 h of hydrogen peroxide treatment.
Formal Description
Interaction-ID: 3981

drug/chemical compound

H2O2

increases_expression of

gene/protein

BCL2L1

in primary astrocytes
Drugbank entries Show/Hide entries for BCL2L1
Comment Oxidative stress increases the protein level of Bcl-xL in primary astrocytes. Transfected glia were treated with H2O2 for 12 h.
Formal Description
Interaction-ID: 3984

drug/chemical compound

H2O2

increases_quantity of

gene/protein

BCL2L1

in primary astrocytes
Drugbank entries Show/Hide entries for BCL2L1
Comment Oxidative stress (100 micro-M H2O2) activates and elevates the level of Ets-2 transcription factor in primary glia.
Formal Description
Interaction-ID: 4001

drug/chemical compound

H2O2

increases_quantity of

gene/protein

ETS2

in primary astrocytes