General Information:

Id: 713
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A
BTO:0001279 spinal cord
article
Reference: Lee J et al.(2009) Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis FASEB J. 23: 1739-1749 [PMID: 19179380]

Interaction Information:

Comment There is an age-dependent increase in GFAP-immunoreactive glial cells within the ventral horn of lumbar spinal cord sections from G93A mice, as compared with wild-type littermate controls. A significant increase was seen at the 90- and 120-day time points, 30- and 70 day time points didn't reveal a significant difference. Astrocytes respond to damage by proliferating and adopting a reactive phenotype characterized by the development of long and thick processes with an increased content of glial fibrillary acidic protein (GFAP)
Formal Description
Interaction-ID: 3954

gene/protein mutant

SOD1-p.G93A

increases_activity of

at 90- and 120-day time points
Comment There is an age-dependent increase in GFAP-immunoreactive glial cells within the ventral horn of lumbar spinal cord sections from G93A mice, as compared with wild-type littermate controls. A significant increase was seen at the 90- and 120-day time points, 30- and 70 day time points didn't reveal a significant difference.
Formal Description
Interaction-ID: 3958

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

GFAP

in astrocytes; at 90- and 120-day time points
Comment Astrocytes respond to damage by proliferating and adopting a reactive phenotype characterized by the development of long and thick processes with an increased content of glial fibrillary acidic protein (GFAP).
Formal Description
Interaction-ID: 3959

increases_quantity of

gene/protein

GFAP

Comment There is an age-dependent increase in Bcl-xL staining in astrocytes seen at the 90- and 120-day time points relative to control mice. The time points 30- and 70 day revealed no significant difference in Bcl-xL immunoreactivity.
Formal Description
Interaction-ID: 3962

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

BCL2L1

in astrocytes; at 90- and 120-day time points
Drugbank entries Show/Hide entries for BCL2L1
Comment Transcripts of GFAP and Bcl-xL were significantly increased in ALS (G93A) mice.
Formal Description
Interaction-ID: 3968

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

GFAP

at 120 days
Comment Transcripts of GFAP and Bcl-xL were significantly increased in ALS (G93A) mice.
Formal Description
Interaction-ID: 3970

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

BCL2L1

at 120 days
Drugbank entries Show/Hide entries for BCL2L1
Comment Oxidative stress up-regulates Bcl-xL mRNA expression in primary astrocytes. The mRNA level of Bcl-xL was increased after 12 h of hydrogen peroxide treatment.
Formal Description
Interaction-ID: 3981

drug/chemical compound

H2O2

increases_expression of

gene/protein

BCL2L1

in primary astrocytes
Drugbank entries Show/Hide entries for BCL2L1
Comment Oxidative stress increases the protein level of Bcl-xL in primary astrocytes. Transfected glia were treated with H2O2 for 12 h.
Formal Description
Interaction-ID: 3984

drug/chemical compound

H2O2

increases_quantity of

gene/protein

BCL2L1

in primary astrocytes
Drugbank entries Show/Hide entries for BCL2L1
Comment Ets-2 drives the transcriptional activation of Bcl-xL in response to oxidative stress.
Formal Description
Interaction-ID: 4000

gene/protein

ETS2

increases_expression of

gene/protein

BCL2L1

in primary astrocytes; induced by oxidative stress
Drugbank entries Show/Hide entries for BCL2L1
Comment Oxidative stress (100 micro-M H2O2) activates and elevates the level of Ets-2 transcription factor in primary glia.
Formal Description
Interaction-ID: 4001

drug/chemical compound

H2O2

increases_quantity of

gene/protein

ETS2

in primary astrocytes
Comment Ets-2 DNA binding sites of the Bcl-xL promoter is required both for the basal and oxidative stress-induced expression of Bcl-xL.
Formal Description
Interaction-ID: 4002

gene/protein

ETS2

increases_expression of

gene/protein

BCL2L1

Drugbank entries Show/Hide entries for BCL2L1
Comment Bcl-xL induction rescues primary astrocytes from oxidative stress-induced cell damage and death.
Formal Description
Interaction-ID: 4004

gene/protein

BCL2L1

decreases_activity of

in primary astrocytes
Drugbank entries Show/Hide entries for BCL2L1
Comment Bcl-xL induction rescues primary astrocytes from oxidative stress-induced cell damage and death.
Formal Description
Interaction-ID: 4120

gene/protein

BCL2L1

decreases_activity of

process

neuron death

in primary astrocytes
Drugbank entries Show/Hide entries for BCL2L1