CIDeRGeneral Information:
| Id: | 7,121 (click here to show other Interactions for entry) |
| Diseases: |
Nephronophthisis
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| Mammalia | |
| review | |
| Reference: | Hildebrandt F et al.(2009) Nephronophthisis: disease mechanisms of a ciliopathy J. Am. Soc. Nephrol. 20: 23-35 [PMID: 19118152] |
Interaction Information:
| Comment | GLIS2 is related to the GLI transcription factor, and these findings implicate the hedgehog pathway in the pathogenesis of cystic kidney diseases. It is a signaling pathway that controls cell determination and tissue patterning during embryogenesis. The other known role of hedgehog is the maintenance of stem cell pools in postembryonic tissues. |
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Formal Description Interaction-ID: 70145 |
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