General Information:

Id: 7,110
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephronophthisis 12 - [OMIM]
Mus musculus
article
Reference: [PMID: 18327258]

Interaction Information:

Comment THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.
Formal Description
Interaction-ID: 70027

gene/protein

TTC21B

decreases_activity of

Comment THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.
Formal Description
Interaction-ID: 70052

gene/protein

TTC21B

affects_activity of

Comment The aln locus encodes a protein, THM1 (tetratricopeptide repeat containing hedgehog modulator-1), which localizes to cilia.
Formal Description
Interaction-ID: 70053

gene/protein

TTC21B

is localized in

cellular component

cilium

Comment aln-mutant cilia have bulb-like structures at their tips in which IFT proteins (such as IFT88) are sequestered, characteristic of Chlamydomonas reinhardtii and Caenorhabditis elegans retrograde IFT mutants. RNA-interference knockdown of Ttc21b (also called Thm1 and which encodes THM1) in mouse inner medullary collecting duct cells expressing an IFT88-enhanced yellow fluorescent protein fusion recapitulated the aln-mutant cilial phenotype, and live imaging of these cells revealed impaired retrograde IFT.
Formal Description
Interaction-ID: 70054

gene/protein

TTC21B

affects_activity of

gene/protein

IFT88

Comment Ttc21b restricts GLI2 activity.
Formal Description
Interaction-ID: 70055

gene/protein

TTC21B

affects_activity of

gene/protein

GLI2

Comment Cilia in aln mutants have abnormal morphology and accumulation of IFT proteins.
Formal Description
Interaction-ID: 70056

gene/protein

TTC21B

affects_activity of