General Information:
Id: | 710 (click here to show other Interactions for entry) |
Diseases: |
Parkinson disease
|
Mammalia | |
BTO:0003945 MN9D cell; BTO:0000298 COS-7 cell | |
article | |
Reference: | Rawal N et al.(2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling Biochem. Biophys. Res. Commun. 388: 473-478 [PMID: 19591802] |
Interaction Information:
Comment | Parkin regulates canonical Wnt/beta-catenin signaling by reducing the pool of active beta-catenin upon Wnt3a stimulation. |
Formal Description Interaction-ID: 3950 |
|
Comment | Wnt3a is a canonical Wnt that binds to Frizzled receptors, preventing phosphorylation of beta-catenin, thereby stabilizing it, allowing it to enter the nucleus and initiate transcription of target genes. |
Formal Description Interaction-ID: 3953 |
|
Comment | Wnt/beta-catenin signaling is important during the development of ventral midbrain DA neurons. |
Formal Description Interaction-ID: 3955 |
process affects_activity of |
Comment | Excessive Wnt/beta-catenin signaling in differentiated ventral midbrain neurons results in cell cycle re-entry followed by DA cell death. |
Formal Description Interaction-ID: 3966 |
process increases_activity of process |