General Information:

Id: 710 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mammalia
BTO:0003945 MN9D cell; BTO:0000298 COS-7 cell
article
Reference: Rawal N et al.(2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling Biochem. Biophys. Res. Commun. 388: 473-478 [PMID: 19591802]

Interaction Information:

Comment Parkin co-localizes and interacts with beta-catenin in DA cells.
Formal Description
Interaction-ID: 3931

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Overexpression of parkin in COS7 cells causes a reduction in the level of endogenous beta-catenin. The second RING domain of Parkin might be important for the regulation of beta-catenin protein levels.
Formal Description
Interaction-ID: 3933

gene/protein

PRKN

decreases_quantity of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Parkin regulates canonical Wnt/beta-catenin signaling by reducing the pool of active beta-catenin upon Wnt3a stimulation.
Formal Description
Interaction-ID: 3950

gene/protein

PRKN

affects_activity of

Comment Overexpression of parkin in COS7 cells causes a reduction in the level of endogenous beta-catenin. The second RING domain of Parkin might be important for the regulation of beta-catenin protein levels.
Formal Description
Interaction-ID: 3974

gene/protein

PRKN

decreases_quantity of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1