General Information:

Id: 7,103 (click here to show other Interactions for entry)
Diseases: Nephronophthisis
Mammalia
review
Reference: [PMID: 25635582]

Interaction Information:

Comment Another signaling pathway involved in the pathogenesis of NPHP is Hedgehog signaling. Nephrocystin-7/GLIS2 was found to alter Hedgehog signaling. Altered Hedgehog signaling was also detected in a mutant nephrocystin-6/cep290 mouse which was found to be a viable model for Joubert syndrome. The Hedgehog pathway seems to be of particular importance regarding skeletal disorders.
Formal Description
Interaction-ID: 69970

gene/protein

CEP290

affects_activity of

process

smoothened signaling pathway