General Information:

Id: 710
Diseases: Parkinson disease
Mammalia
BTO:0003945 MN9D cell; BTO:0000298 COS-7 cell
article
Reference: Rawal N et al.(2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling Biochem. Biophys. Res. Commun. 388: 473-478 [PMID: 19591802]

Interaction Information:

Comment Parkin co-localizes and interacts with beta-catenin in DA cells.
Formal Description
Interaction-ID: 3931

gene/protein

PARK2

interacts (colocalizes) with

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Overexpression of parkin in COS7 cells causes a reduction in the level of endogenous beta-catenin. The second RING domain of Parkin might be important for the regulation of beta-catenin protein levels.
Formal Description
Interaction-ID: 3933

gene/protein

PARK2

decreases_quantity of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Parkin regulates canonical Wnt/beta-catenin signaling by reducing the pool of active beta-catenin upon Wnt3a stimulation.
Formal Description
Interaction-ID: 3950

gene/protein

PARK2

affects_activity of

Comment Wnt3a is a canonical Wnt that binds to Frizzled receptors, preventing phosphorylation of beta-catenin, thereby stabilizing it, allowing it to enter the nucleus and initiate transcription of target genes.
Formal Description
Interaction-ID: 3951

gene/protein

WNT3A

increases_activity of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Wnt3a is a canonical Wnt that binds to Frizzled receptors, preventing phosphorylation of beta-catenin, thereby stabilizing it, allowing it to enter the nucleus and initiate transcription of target genes.
Formal Description
Interaction-ID: 3952

gene/protein

WNT3A

decreases_phosphorylation of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Wnt3a is a canonical Wnt that binds to Frizzled receptors, preventing phosphorylation of beta-catenin, thereby stabilizing it, allowing it to enter the nucleus and initiate transcription of target genes.
Formal Description
Interaction-ID: 3953

gene/protein

WNT3A

affects_activity of

Comment Wnt/beta-catenin signaling is important during the development of ventral midbrain DA neurons.
Formal Description
Interaction-ID: 3955
Comment Treatment of differentiated primary DA neurons with Wnt3a (50 ng/ml) for 24 h increased the levels of beta-catenin, cyclin E and cleaved PARP.
Formal Description
Interaction-ID: 3961

gene/protein

WNT3A

increases_quantity of

gene/protein

CTNNB1

in dopaminergic neurons
Drugbank entries Show/Hide entries for CTNNB1
Comment Treatment of differentiated primary DA neurons with Wnt3a (50 ng/ml) for 24 h increased the levels of beta-catenin, cyclin E and cleaved PARP.
Formal Description
Interaction-ID: 3963

gene/protein

WNT3A

increases_quantity of

gene/protein

Cyclin E

in dopaminergic neurons
Comment Wnt3a is known to induce cell proliferation through stabilization of beta-catenin.
Formal Description
Interaction-ID: 3964

gene/protein

WNT3A

increases_activity of

Comment Excessive Wnt/beta-catenin signaling in differentiated ventral midbrain neurons results in cell cycle re-entry followed by DA cell death.
Formal Description
Interaction-ID: 3966

increases_activity of

in differentiated ventral midbrain neurons
Comment Excessive Wnt/beta-catenin signaling in differentiated ventral midbrain neurons results in cell cycle re-entry followed by DA cell death.
Formal Description
Interaction-ID: 3969

increases_activity of

process

neuron death

in differentiated ventral midbrain neurons
Comment Overexpression of parkin in COS7 cells causes a reduction in the level of endogenous beta-catenin. The second RING domain of Parkin might be important for the regulation of beta-catenin protein levels.
Formal Description
Interaction-ID: 3974

gene/protein

PARK2

decreases_quantity of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1