General Information:

Id: 71
Diseases: Diabetes mellitus, type I - [OMIM]
Rattus norvegicus
BTO:0001185 RINm5F cell
article
Reference: Kim EK et al.(2007) Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway. Int. J. Biochem. Cell Biol. 39: 1260-1275 [PMID: 17521952]

Interaction Information:

Comment Cytokine (IL-1-beta and IFN-gamma) treatment reduced the proliferative potential of the cells.
Formal Description
Interaction-ID: 217

gene/protein

IL1B

decreases_activity of

Drugbank entries Show/Hide entries for IL1B
Comment The thiazolidinediones (high affinity ligands for PPAR-gamma) CGZ and TGZ prevented the cytokine-mediated decrease in cell proliferation potential.
Formal Description
Interaction-ID: 218

drug/chemical compound

Troglitazone

increases_activity of

in cytokine treated cells
Drugbank entries Show/Hide entries for Troglitazone
Comment The thiazolidinediones (high affinity ligands for PPAR-gamma) CGZ and TGZ prevented the cytokine-mediated decrease in cell proliferation potential.
Formal Description
Interaction-ID: 219

drug/chemical compound

Ciglitazone

increases_activity of

in cytokine treated cells
Comment Cytokine (IL-1-beta and IFN-gamma) treatment markedly increased iNOS and COX-2 mRNA and protein expression, whereas cells pretreated with TGZ or CGZ showed suppressed expression of iNOS and COX-2 in both their mRNA and protein levels.
Formal Description
Interaction-ID: 220

gene/protein

IL1B

increases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for IL1B or NOS2
Comment Cytokine (IL-1-beta and IFN-gamma) treatment markedly increased iNOS and COX-2 mRNA and protein expression, whereas cells pretreated with TGZ or CGZ showed suppressed expression of iNOS and COX-2 in both their mRNA and protein levels.
Formal Description
Interaction-ID: 221

gene/protein

IL1B

increases_expression of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for IL1B or PTGS2
Comment Cytokine (IL-1-beta and IFN-gamma) treatment markedly increased iNOS and COX-2 mRNA and protein expression, whereas cells pretreated with TGZ or CGZ showed suppressed expression of iNOS and COX-2 in both their mRNA and protein levels.
Formal Description
Interaction-ID: 222

drug/chemical compound

Troglitazone

decreases_expression of

gene/protein

NOS2

in cytokine treated cells
Drugbank entries Show/Hide entries for Troglitazone or NOS2
Comment Cytokine (IL-1-beta and IFN-gamma) treatment markedly increased iNOS and COX-2 mRNA and protein expression, whereas cells pretreated with TGZ or CGZ showed suppressed expression of iNOS and COX-2 in both their mRNA and protein levels.
Formal Description
Interaction-ID: 223

drug/chemical compound

Ciglitazone

decreases_expression of

gene/protein

NOS2

in cytokine treated cells
Drugbank entries Show/Hide entries for NOS2
Comment Cytokine (IL-1-beta and IFN-gamma) treatment markedly increased iNOS and COX-2 mRNA and protein expression, whereas cells pretreated with TGZ or CGZ showed suppressed expression of iNOS and COX-2 in both their mRNA and protein levels.
Formal Description
Interaction-ID: 224

drug/chemical compound

Troglitazone

decreases_expression of

gene/protein

PTGS2

in cytokine treated cells
Drugbank entries Show/Hide entries for Troglitazone or PTGS2
Comment Cytokine (IL-1-beta and IFN-gamma) treatment markedly increased iNOS and COX-2 mRNA and protein expression, whereas cells pretreated with TGZ or CGZ showed suppressed expression of iNOS and COX-2 in both their mRNA and protein levels.
Formal Description
Interaction-ID: 225

drug/chemical compound

Ciglitazone

decreases_expression of

gene/protein

PTGS2

in cytokine treated cells
Drugbank entries Show/Hide entries for PTGS2
Comment Cytokine (IL-1-beta and IFN-gamma) treatment showed inceases in p65 subunit levels in their nucleus.
Formal Description
Interaction-ID: 232

gene/protein

IL1B

increases_transport of

gene/protein

RELA

into nucleus
Drugbank entries Show/Hide entries for IL1B or RELA
Comment The thiazolidinediones (high affinity ligands for PPAR-gamma) CGZ and TGZ prevented the cytokine-mediated translocation of p65 into nucleus.
Formal Description
Interaction-ID: 234

drug/chemical compound

Troglitazone

decreases transport of

gene/protein

RELA

into nucleus; in cytokine treated cells
Drugbank entries Show/Hide entries for Troglitazone or RELA
Comment The thiazolidinediones (high affinity ligands for PPAR-gamma) CGZ and TGZ prevented the cytokine-mediated translocation of p65 into nucleus.
Formal Description
Interaction-ID: 235

drug/chemical compound

Ciglitazone

decreases transport of

gene/protein

RELA

into nucleus; in cytokine treated cells
Drugbank entries Show/Hide entries for RELA
Comment Overexpression of PPAR-gamma caused dramatic decreases in the iNOS and COX-2 mRNA levels induced by IL-1-beta and IFN-gamma in the absence of any exogenous PPAR-gamma ligands.
Formal Description
Interaction-ID: 237

gene/protein

PPARG

decreases_expression of

gene/protein

NOS2

if PPARG is overexpressed in cytokine treated cells
Drugbank entries Show/Hide entries for PPARG or NOS2
Comment Overexpression of PPAR-gamma caused dramatic decreases in the iNOS and COX-2 mRNA levels induced by IL-1-beta and IFN-gamma in the absence of any exogenous PPAR-gamma ligands.
Formal Description
Interaction-ID: 238

gene/protein

PPARG

decreases_expression of

gene/protein

PTGS2

if PPARG is overexpressed in cytokine treated cells
Drugbank entries Show/Hide entries for PPARG or PTGS2
Comment Cytokine (IL-1-beta and IFN-gamma) treatment showed increased I-kappa-B-alpha degradation in the cytosol.
Formal Description
Interaction-ID: 243

gene/protein

IL1B

decreases_quantity of

gene/protein

NFKBIA

in cytosol; in cytokine treated cells
Drugbank entries Show/Hide entries for IL1B
Comment Cytokine (IL-1-beta and IFN-gamma) treatment did not affect protein levels of IKBB in the cytosol.
Formal Description
Interaction-ID: 244

gene/protein

IL1B

NOT decreases_quantity of

gene/protein

NFKBIB

in cytosol; in cytokine treated cells
Drugbank entries Show/Hide entries for IL1B
Comment Increased I-kappa-B-alpha degradation by cytokines was markedly suppressed by either the addition of PPAR-gamma ligands (TGZ, CGZ) or the overexpression of PPAR-gamma.
Formal Description
Interaction-ID: 245

drug/chemical compound

Troglitazone

increases_quantity of

gene/protein

NFKBIA

in cytosol; in cytokine treated cells
Drugbank entries Show/Hide entries for Troglitazone
Comment Increased I-kappa-B-alpha degradation by cytokines was markedly suppressed by either the addition of PPAR-gamma ligands (TGZ, CGZ) or the overexpression of PPAR-gamma.
Formal Description
Interaction-ID: 246

drug/chemical compound

Ciglitazone

increases_quantity of

gene/protein

NFKBIA

in cytosol; in cytokine treated cells
Comment Increased I-kappa-B-alpha degradation by cytokines was markedly suppressed by either the addition of PPAR-gamma ligands (TGZ, CGZ) or the overexpression of PPAR-gamma.
Formal Description
Interaction-ID: 247

gene/protein

PPARG

increases_quantity of

gene/protein

NFKBIA

in cytosol; if PPARG is overexpressed in cytokine treated cells
Drugbank entries Show/Hide entries for PPARG
Comment Cytokine (IL-1-beta and IFN-gamma) treatment did not show increased degradation of I-kappa-B-alpha mutant (S32A, S36A) in the cytosol.
Formal Description
Interaction-ID: 248

gene/protein

IL1B

NOT decreases_quantity of

gene/protein mutant

NFKBIA-p.S32A-S36A

in cytosol
Drugbank entries Show/Hide entries for IL1B
Comment I-kappa-B-alpha mutant (S32A, S36A) reduced the mRNA and protein levels of iNOS and COX-2, if overexpressed in cytokine treated cells.
Formal Description
Interaction-ID: 249

gene/protein mutant

NFKBIA-p.S32A-S36A

decreases_expression of

gene/protein

NOS2

if overexpressed in cytokine treated cells
Drugbank entries Show/Hide entries for NOS2
Comment I-kappa-B-alpha mutant (S32A, S36A) reduced the mRNA and protein levels of iNOS and COX-2, if overexpressed in cytokine treated cells.
Formal Description
Interaction-ID: 250

gene/protein mutant

NFKBIA-p.S32A-S36A

decreases_expression of

gene/protein

PTGS2

if overexpressed in cytokine treated cells
Drugbank entries Show/Hide entries for PTGS2
Comment Cytokine (IL-1-beta and IFN-gamma) treatment showed increased DNA binding and transcriptional activities of NF-kappa-B.
Formal Description
Interaction-ID: 270

gene/protein

IL1B

increases_activity of

Drugbank entries Show/Hide entries for IL1B